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Clinical trials
Analytical treatment interruptions: minimising the risks and maximising their scientific value

Recommendations for the safe and appropriate use of ‘analytical treatment interruptions’ have been developed by a group of HIV experts, including clinicians, patient advocates, bioethicists, social scientists and

Published
15 May 2019
By
Alain Volny-Anne
Clinical trials
Despite Uptick, Black and Latinx People Have Relatively Low Participation in HIV Vaccine Trials

Black and Latinx people historically have not willfully participated in clinical trials in high numbers. Medical mistrust of research and health care institutions has long been a problem for conducting biomedical research. So what's causing the racial disparities in research participation, and what are researchers doing about it?

Published
14 May 2019
From
The Body Pro
Transgender people
The largest study involving transgender people is providing long-sought insights about their health

The research examines once taboo questions about the impacts of gender transition. The European Network for the Investigation of Gender Incongruence (ENIGI) is the largest scientific study of transgender people in the world, now with 2600 participants, and is unique because it is prospective, studying the impact of hormone and other therapies on their health over the long term.

Published
25 April 2019
From
Nature
Clinical trials
Why Do Study Participants Misreport Their HIV Status?

Why do some study volunteers misreport their HIV status to researchers? Maybe they misunderstood the conditions for incentive payments or the question itself, speculated the authors of a recent study on the subject. Or maybe the questions were not phrased in a way that is easy for laypersons to understand, countered David Malebranche, M.D., M.P.H., of Morehouse School of Medicine.

Published
24 April 2019
From
The Body Pro
Clinical trials
Effective HIV Interventions Have Changed the Approach to Trials

In the past, individuals who were at high risk for HIV infection and who were enrolled in placebo-controlled prevention trials had been typically randomly assigned to either an experimental agent or placebo. However, that trial design—and the way those trials were interpreted—has shifted. This was the topic of discussion during David Dunn’s session yesterday at the Conference on Retroviruses and Opportunistic Infections (CROI) 2019. Dunn is a researcher at University College London in the United Kingdom.

Published
11 March 2019
From
Infectious Diseases Consultant
Treatment interruptions
HIV-positive participant in vaccine study passes virus to sexual partner during treatment interruption

An HIV-positive man transmitted HIV to his sexual partner after interrupting antiretroviral therapy as part of a research study into a therapeutic vaccine, French scientists reported in

Published
01 March 2019
By
Roger Pebody
Clinical trials
Mind the Gap: The Burden of HIV Among Racial and Ethnic Minority Groups and Their Participation in Preventive HIV Vaccine Clinical Trials

An analysis conducted by the HIV Vaccine Trials Network (HVTN) observed an overall increase in the proportion of racial and ethnic minorities enrolled in Phase 1 and Phase 2A preventive HIV vaccine clinical trials in the United States between 2002 and 2016 compared to 1988 to 2002. The findings were published on December 5, 2018 in Public Health Reports.

Published
16 February 2019
From
HIV Vaccine Trials Network
PrEP programmes and uptake
While The NHS Drags Its Heels On PrEP, This Is How Men Are Being Affected

Although NHS England increased places in the PrEP Impact Trial to 13,000 participants in summer and recently said it hopes to extend this to 26,000 before 2020, it is yet to confirm when these places will become available – or what will happen when the three-year trial is up. Around 40% of trial clinics across England are currently turning away gay and bisexual men due to oversubscription, according to the Terrence Higgins Trust. Six men who’ve failed to access PrEP have told HuffPost UK the experience has left them feeling “depressed”, “anxious” and “frustrated”.

Published
12 February 2019
From
Huffington Post
Clinical trials
Correlation between HIV, rectal gonorrhea could help PrEP trial designs

Rectal gonorrhea incidence may serve to estimate what HIV incidence would have been had trial participants not received PrEP, according to study findings.

Published
12 February 2019
From
Healio
Clinical trials
Family duty is a powerful force in China. Is that why so many couples signed up for the ‘CRISPR babies’ experiment?

Young adults in China feel a powerful cultural obligation to marry and have kids, but that life plan suddenly looks unattainable to people told they’re infected with HIV, particularly for the many who can’t afford or are unaware of treatments that would allow them to have uninfected children. So when an ambitious scientist offered HIV-positive men and their spouses what seemed to be a way out of this despair, several hundred couples in China jumped at the chance, expressing interest in a clinical trial that promised to deliver them babies forever protected from HIV infections.

Published
15 January 2019
From
STAT
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Community Consensus Statement on Access to HIV Treatment and its Use for Prevention

Together, we can make it happen

We can end HIV soon if people have equal access to HIV drugs as treatment and as PrEP, and have free choice over whether to take them.

Launched today, the Community Consensus Statement is a basic set of principles aimed at making sure that happens.

The Community Consensus Statement is a joint initiative of AVAC, EATG, MSMGF, GNP+, HIV i-Base, the International HIV/AIDS Alliance, ITPC and NAM/aidsmap
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